Analogs of Monensin with Na ' / K ' Selectivitya Modified C 2 s - C 26 Moiety : and Biological Activity
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چکیده
alkaline complexes by X-ray crystallography,8) Seyeral studies on the chemical modification of the monensin skeleton have been reported, either on the Ci-Cs carboxylic moiety,9・iO) or at the C,,-hydroxyl group,ii) fo11owing the isolation of antibiotics X-14667A and Bi2) (monensin C26-phenethyl urethans). We have shown that the C26-chloro-4 phenyl urethan derivative had a transport selectivity, with K'>Na+ in a chlorofbrm phase.7J AG, ziH and AS of complexation measured simul-
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